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Quick Details

  • Type: Herbal Extract
  • Variety: Other
  • Form: Powder
  • Part: Other
  • Extraction Type: Solvent Extraction
  • Packaging: Drum
  • Place of Origin: China (Mainland)
  • Grade: Food Grade and Pharmaceutical Grade
  • Brand Name: Plamed
  • Model Number: PM0038
  • Packing: 25kg/drum
  • Botanical Source: Glycine max (L.)Merr
  • Sample: Free
  • Usage: Pharmaceutical, cosmetic and food
  • Specification: Nattokinase 12000FU/G, 20000FU/G
  • Standard: In house,USP,JP,EP,BP
  • Color: Yellow-white
  • Appearance: Yellow-white fine powder
  • Test: HPLC

Packaging & Delivery

Packaging Details: 25kgs/drum, inner by double plastic bag, 1~20kg by aluminum foil vacuum bag.
Delivery Detail: 3-5 working days
Product Overview

 

Nattokinase, a potent fibrinolytic enzyme, is one of many enzymes derived from a popular Japanese food called natto. It has been found to have blood clot dissolving abilities and prevents the aggregation of red blood cells. It is used to make anti-clotting medicine.

About the measurement (fu/g): The potency of nattokinase is often measured by the enzyme’s ability to degrade fibrin over a given amount of time, and is represented by Fibrinolytic Units.


Active ingredient:

Nattokinase

CAS Number:

133876-92-3

 

 

 

Botanical Source

 Natto is a traditional Japanese fermented soybean dish and dietary staple that has been used in Japanese culture for more than 1,000 years for its popular taste. Natto is simple to make, requiring only soybeans, straw and water. Steamed beans are mixed with straw, which contains the bacteria Bacillus subtilis, and left to ferment for 24 hours. The resulting product is sticky and has a stringy, web-like consistency. It has been used as a folk remedy for heart and vascular diseases.

 

Specification

 

ANALYSIS

SPECIFICATION

Assay

Nattokinase 5000FU/g, 20000FU/g

Organoleptic

Appearance

White Fine Powder

Odor

Deodorization

Source

Natto (Fermented soybeans)

Physical Characteristics

Partical size

95%Through 80 Mesh

Loss on Drying

≤7%

Vitamin K2

≤10ppm

Soy Isoflavone

Negative

Purine

Negative

Solubility

Water Soluble

Heavy Metals

Total Heavy Metals

≤10PPM

Arsenic

≤2PPM

Pb

≤2PPM

Microbiological Tests

Total Plate Count

≤1000cfu/g

Total Yeast & Mold

≤100cfu/g

E.Coli

Negative

Salmonella

Negative

Staphylococcus

Negative

Production Flow

 

Benefits and dosage

 Anti-clotting and Fibrinolysis

Nattokinase exhibits direct fibrinolytic properties that may degrade fibrin and reduce the risk of cardiovascular complications. This direct activity is lost upon destruction of the enzyme (heat treatment or digestion), but the peptides from nattokinase appear to increase levels of plasminogen activator which also has a fibrinolytic effect indirectly. The fibrinolytic activity of nattokinase is reportedly 4 times that of plasmin.

High blood pressure

Research suggests that prolonged supplementation (about 8 weeks) of nattokinase daily can reduce systolic and diastolic blood pressure in people with mildly high blood pressure. Nattokinase appears to exert mixed-type inhibition on the Angiotensin Converting Enzyme, and this is thought to be related not to enzyme activity but due to bioactive peptides from nattokinase. The byproducts of enzyme digestion (when the enzyme nattokinase is destroyed) appear to be bioactive dipeptides and tripeptides, which have ACE inhibitory potential or may otherwise reduce blood pressure

Deep vein thrombosis (DVT)

Nattokinase can be used for the prevention of deep vein thrombosis (DVT) during long airline flights (7-8 hours). Nattokinase, in combination with pycnogenol, was reported to decrease the chance of getting a blood clot in the legs determined by ultrasound of the venous system during long flights. Edema scores were also reduced, possibly due to the diuretic effect of pycnogenol.

2000FU-6000FU daily, taken with meals is recommended.

Recommended Dosage for different specification

Specification

Recommended Dosage

5000FU/g

400-1200mg/day

20000FU/g

100-300mg/day

Application

 

Application

Form

Purpose

Medical and health industry

Soft gel capsules; hard shell capsules; tablets

Anti-clotting,
cardiovascular health

Food industry

Functional food

Cardiovascular health

Safety
  • Nattokinase is very safe when used according to the recommended dosage. The traditional Japanese food Natto has been used safely for more than 1,000 years. The safety record of its potent fibrinolytic enzyme, Nattokinase, is based upon the long-term traditional use of the food and recent scientific studies.
  • Generally, people with bleeding disorders, or taking anti-clotting medication, should use this product only under the close supervision of a medical doctor.
Packing and Storage

 Packed in 25kg paper drums with two plastic bags inside.

Please store in well closed containers away from moisture and heat.

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